ВЗАИМОСВЯЗЬ МЕЖДУ КУРЕНИЕМ И АНТИАГРЕГАНТНЫМ ДЕЙСТВИЕМ КЛОПИДОГРЕЛА


Авторы

Ключевые слова:

клопидогрел, тромбоциты, антиагреганты, курение, парадокс курильщика

Аннотация

Клопидогрел является наиболее часто используемым антиагрегантным препаратом из группы ингибиторов P2Y12, которые активно применяются для вторичной профилактики атеротромботических сердечно-сосудистых событий ишемического генеза у пациентов, перенесших инфаркт миокарда и стентирование коронарных артерий. С учётом сложности метаболизма препарата и большого количества потенциальных лекарственных взаимодействий остро стоит проблема индивидуальной вариабельности антиагрегантного действия клопидогрела. Кроме того, одним из клинически значимых вопросов является так называемый «парадокс курильщика». Суть данного феномена заключается в том, что у ряда пациентов курение повышает эффективность антиагрегантного действия клопидогрела. В настоящем обзоре проанализированы данные зарубежных исследований последних лет об особенностях фармакокинетики и фармакодинамики клопидогрела у курящих, потенциальных причинах возникновения «парадокса курильщика» и о его возможном клиническом значении у пациентов с ишемической болезнью сердца. Затрагивается вопрос сравнительной эффективности различных представителей класса ингибиторов P2Y12, в том числе с точки зрения влияния курения. Обсуждаются фармакогенетические аспекты и проблемы персонализации антиагрегантной терапии.

Библиографические ссылки

Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol. 2007;49(14):1505-1516. DOI: 10.1016/j.jacc.2006.11.044.

Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352(12):1179-1189. DOI: 10.1056/NEJMoa050522.

Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502. DOI: 10.1056/NEJMoa010746.

Chen ZM, Jiang LX, Chen YP, et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366(9497):1607-1621. DOI: 10.1016/S0140-6736(05)67660-X.

Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358(9281):527-533. DOI: 10.1016/s0140-6736(01)05701-4.

Lewis BS, Mehta SR, Fox KA, et al. Benefit of clopidogrel according to timing of percutaneous coronary intervention in patients with acute coronary syndromes: further results from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study. Am Heart J. 2005;150(6):1177-1184. DOI: 10.1016/j.ahj.2005.01.044.

Steinhubl SR, Berger PB, Mann JT 3rd, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial [published correction appears in JAMA. 2003 Feb 26;289(8):987.]. JAMA. 2002;288(19):2411-2420. DOI: 10.1001/jama.288.19.2411.

Eshaghian S, Kaul S, Amin S, et al. Role of clopidogrel in managing atherothrombotic cardiovascular disease. Ann Intern Med. 2007;146(6):434-441. DOI: 10.7326/0003-4819-146-6-200703200-00008.

Knuuti J, Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC). Eur Heart J. 2020;41(3):407–477. DOI: 10.1093/eurheartj/ehz425.

Valgimigli M, Bueno H, Byrne RA, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J. 2018;14(3):213-260. DOI: 10.1093/eurheartj/ehx419.

Collet JP, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2020; ehaa575. DOI: 10.1093/eurheartj/ehaa575.

Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(2):119-177. DOI: 10.1093/eurheartj/ehx393.

Münzel T, Hahad O, Kuntic M, et al. Effects of tobacco cigarettes, e-cigarettes, and waterpipe smoking on endothelial function and clinical outcomes. Eur Heart J. 2020;41(41):4057-4070. DOI: 10.1093/eurheartj/ehaa460.

Лындина М.Л., Шишкин А.Н. Клинические особенности эндотелиальной дисфункции при ожирении и роль фактора курения // Регионарное кровообращение и микроциркуляция. 2018. Т. 17. № 2. С. 18-25. [Lyndina ML, Shishkin AN. Clinical features of endothelial dysfunctions in patients with obesity and role of smoking. Regional hemodynamics and microcirculation. 2018;17(2):20-27. (in Russ)]. DOI: 10.24884/1682-6655-2018-17-2-18-25 .

Barbieri SS, Zacchi E, Amadio P, et al. Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction. Cardiovasc Res. 2011;90(3):475-483. DOI: 10.1093/cvr/cvr032.

Messner B, Bernhard D. Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol. 2014;34(3):509-515. DOI: 10.1161/ATVBAHA.113.300156.

Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost. 2005;31(2):174-183. DOI: 10.1055/s-2005-869523.

Fitzgerald DJ, Maree A. Aspirin and clopidogrel resistance. Hematology Am Soc Hematol Educ Program. 2007;114-120. DOI: 10.1182/asheducation-2007.1.114.

Simon N, Finzi J, Cayla G, et al. Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients. Eur J Clin Pharmacol. 2015;71(9):1059-1066. DOI: 10.1007/s00228-015-1882-3.

Kazui M, Nishiya Y, Ishizuka T, et al. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug Metab Dispos. 2010;38(1):92-99. DOI: 10.1124/dmd.109.029132.

Li XQ, Andersson TB, Ahlström M, Weidolf L. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004;32(8):821-827. DOI: 10.1124/dmd.32.8.821.

Angiolillo DJ, Gibson CM, Cheng S, et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther. 2011;89(1):65-74. DOI: 10.1038/clpt.2010.219.

Reed GW, Cannon CP, Waalen J, et al. Influence of smoking on the antiplatelet effect of clopidogrel differs according to clopidogrel dose: Insights from the GRAVITAS trial. Catheter Cardiovasc Interv. 2017;89(2):190-198. DOI: 10.1002/ccd.26428.

Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal Bioanal Chem. 2008;392(6):1093-1108. DOI: 10.1007/s00216-008-2291-6.

Swiger KJ, Yousuf O, Bliden KP, et al. Cigarette smoking and clopidogrel interaction. Curr Cardiol Rep. 2013;15(5):361. DOI: 10.1007/s11886-013-0361-7.

Rasmussen BB, Brix TH, Kyvik KO, Brøsen K. The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics. 2002;12(6):473-478. DOI: 10.1097/00008571-200208000-00008.

Zhou SF, Wang B, Yang LP, Liu JP. Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab Rev. 2010;42(2):268-354. DOI: 10.3109/03602530903286476.

Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol. 1999;47(4):445-449. DOI: 10.1046/j.1365-2125.1999.00898.x.

Park KW, Park JJ, Jeon KH, et al. Enhanced clopidogrel responsiveness in smokers: smokers' paradox is dependent on cytochrome P450 CYP1A2 status. Arterioscler Thromb Vasc Biol. 2011;31(3):665-671. DOI: 10.1161/ATVBAHA.110.217182.

Koonrungsesomboon N, Khatsri R, Wongchompoo P, Teekachunhatean S. The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis. Pharmacogenomics J. 2018;18(6):760-768. DOI: 10.1038/s41397-017-0011-3.

Djordjevic N, Ghotbi R, Bertilsson L, et al. Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes. Eur J Clin Pharmacol. 2008;64(4):381-385. DOI: 10.1007/s00228-007-0438-6.

Ghotbi R, Christensen M, Roh HK, et al. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol. 2007;63(6):537-546. DOI: 10.1007/s00228-007-0288-2.

Shanker G, Kontos JL, Eckman DM, et al. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts. J Thromb Thrombolysis. 2006;22(3):213-220. DOI: 10.1007/s11239-006-9033-4.

Sambola A, Osende J, Hathcock J, et al. Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity. Circulation. 2003;107(7):973-977. DOI: 10.1161/01.cir.0000050621.67499.7d.

Gupta T, Kolte D, Khera S, et al. Smoker's Paradox in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. J Am Heart Assoc. 2016;5(4):e003370. DOI: 10.1161/JAHA.116.003370.

Hochholzer W, Trenk D, Mega JL, et al. Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy. Am Heart J. 2011;162(3):518-26.e5. DOI: 10.1016/j.ahj.2011.06.005.

Yousef AM, Arafat T, Bulatova NR, Al-Zumyli R. Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel. J Clin Pharm Ther. 2008;33(4):439-449. DOI: 10.1111/j.1365-2710.2008.00936.x.

Bliden KP, Dichiara J, Lawal L, et al. The association of cigarette smoking with enhanced platelet inhibition by clopidogrel. J Am Coll Cardiol. 2008;52(7):531-533. DOI: 10.1016/j.jacc.2008.04.045.

Desai NR, Mega JL, Jiang S, Cannon CP, Sabatine MS. Interaction between cigarette smoking and clinical benefit of clopidogrel. J Am Coll Cardiol. 2009;53(15):1273-1278. DOI: 10.1016/j.jacc.2008.12.044.

Ramotowski B, Gurbel PA, Tantry U, et al. Effect of Smoking Cessation on the Pharmacokinetics and Pharmacodynamics of Clopidogrel after PCI: The Smoking Cessation Paradox Study. Thromb Haemost. 2020;120(3):449-456. DOI: 10.1055/s-0039-3402758.

Tantry US, Bonello L, Aradi D, et al. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol. 2013;62(24):2261-2273. DOI: 10.1016/j.jacc.2013.07.101

Park KW, Kang SH, Kang J, et al. Enhanced clopidogrel response in smokers is reversed after discontinuation as assessed by VerifyNow assay: additional evidence for the concept of 'smokers' paradox'. Heart. 2012;98(13):1000-1006. DOI: 10.1136/heartjnl-2011-301565.

Ferreiro JL, Bhatt DL, Ueno M, et al. Impact of smoking on long-term outcomes in patients with atherosclerotic vascular disease treated with aspirin or clopidogrel: insights from the CAPRIE trial (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events). J Am Coll Cardiol. 2014;63(8):769-777. DOI: 10.1016/j.jacc.2013.10.043.

Gurbel PA, Bliden KP, Logan DK, et al. The influence of smoking status on the pharmacokinetics and pharmacodynamics of clopidogrel and prasugrel: the PARADOX study. J Am Coll Cardiol. 2013;62(6):505-512. DOI: 10.1016/j.jacc.2013.03.037.

Gagne JJ, Bykov K, Choudhry NK, et al. Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison. BMJ. 2013;347:f5307. DOI: 10.1136/bmj.f5307.

Liu Z, Xiang Q, Mu G, et al. Effectiveness and Safety of Platelet ADP -P2Y12 Receptor Inhibitors Influenced by Smoking Status: A Systematic Review and Meta-Analysis. J Am Heart Assoc. 2019;8(7):e010889. DOI: 10.1161/JAHA.118.010889.

Li M, Feng L, Li X, et al. Influences of Smoking Status on Effectiveness of Cytochrome P450 Enzyme System Metabolized Medications in Reducing In-Hospital Death in 14 658 Patients With Acute Myocardial Infarction: Data From CPACS-3 Study. J Cardiovasc Pharmacol Ther. 2020;25(5):418-424. DOI: 10.1177/1074248420921304.

Valenti R, Marcucci R, Comito V, et al. Prasugrel in Clopidogrel Nonresponders Undergoing Percutaneous Coronary Intervention: The RECLOSE-3 Study (REsponsiveness to CLOpidogrel and StEnt Thrombosis). JACC Cardiovasc Interv. 2015;8(12):1563-1570. DOI: 10.1016/j.jcin.2015.07.010.

Sibbald M, Yan AT, Huang W, et al. Association between smoking, outcomes, and early clopidogrel use in patients with acute coronary syndrome: insights from the Global Registry of Acute Coronary Events. Am Heart J. 2010;160(5):855-861. DOI: 10.1016/j.ahj.2010.07.026.

Berger JS, Bhatt DL, Steinhubl SR, et al. Smoking, clopidogrel, and mortality in patients with established cardiovascular disease. Circulation. 2009;120(23):2337-2344. DOI: 10.1161/CIRCULATIONAHA.109.866533.

Sibbing D, Bernlochner I, Schulz S, et al. The impact of smoking on the antiplatelet action of clopidogrel in non-ST-elevation myocardial infarction patients: results from the ISAR-REACT 4 platelet substudy. J Thromb Haemost. 2012;10(10):2199-2202. DOI: 10.1111/j.1538-7836.2012.04867.x.

Cornel JH, Ohman EM, Neely B, et al. Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial [published correction appears in Am Heart J. 2014 Oct;168(4):605]. Am Heart J. 2014;168(1):76-87.e1. DOI: 10.1016/j.ahj.2014.04.011.

Patti G, Polacco M, Taurino E, et al. Effects of cigarette smoking on platelet reactivity during P2Y12 inhibition in patients with myocardial infarction undergoing drug-eluting stent implantation: results from the prospective cigarette smoking on platelet reactivity (COPTER) study. J Thromb Thrombolysis. 2016;41(4):648-653. DOI: 10.1007/s11239-016-1341-8.

Gupta R, Kirtane AJ, Liu Y, et al. Impact of Smoking on Platelet Reactivity and Clinical Outcomes After Percutaneous Coronary Intervention: Findings From the ADAPT-DES Study. Circ Cardiovasc Interv. 2019;12(11):e007982. DOI: 10.1161/CIRCINTERVENTIONS.119.007982.

Stone GW, Witzenbichler B, Weisz G, et al. Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study [published correction appears in Lancet. 2014 Mar 29;383(9923):1128]. Lancet. 2013;382(9892):614-623. DOI: 10.1016/S0140-6736(13)61170-8.

Загрузки


Просмотров аннотации: 5

Опубликован

30.10.2020

Как цитировать

1.
Лукьянец КЮ, Лындина МЛ. ВЗАИМОСВЯЗЬ МЕЖДУ КУРЕНИЕМ И АНТИАГРЕГАНТНЫМ ДЕЙСТВИЕМ КЛОПИДОГРЕЛА. Juvenis Scientia [Интернет]. 30 октябрь 2020 г. [цитируется по 3 август 2021 г.];6(5):14-2. доступно на: https://en.jscientia.org/index.php/js/article/view/19

Выпуск

Раздел

ОБЗОРНЫЕ СТАТЬИ