Мavlyanova ShZ, Mutavaliev MS, Ismogilov AI, Mullakhanov JB, Alimukhamedova YuA. Assessment of IgG autoantibodies to single-stranded DNA (ss- DNA) and double-stranded DNA (ds- DNA) in patients with acantholytic pemphigus. Juvenis scientia. 2020;6(4):57-62.
ASSESSMENT OF IgG AUTOANTIBODIES TO SINGLE-STRANDED DNA (ss-DNA) AND DOUBLE-STRANDED DNA (ds-DNA) IN PATIENTS WITH ACANTHOLYTIC PEMPHIGUS
Sh. Z. Мavlyanova, M. S. Mutavaliev, A. I. Ismogilov,
J. B. Mullakhanov, Yu. A. Alimukhamedova
Republican Specialized Scientific and Practical Medical Center
of Dermatovenerology and Cosmetology
3 Faraby St., 100109 Tashkent, Uzbekistan
In recent years, evaluation of autoimmune mechanisms of bullous dermatoses has become relevant. In this connection, the aim of our study was to assess serum levels of IgG autoantibodies (AAB) to single stranded DNA (ss-DNA) and double stranded DNA (ds-DNA) in patients with true acantholytic pemphigus. The present study included 57 patients with acantholytic pemphigus and 18 healthy individuals (control group). Analysis of the results obtained showed that most patients with true pemphigus had an increased level of IgG autoantibodies to ds-DNA (59.6% of cases). At the same time, IgG autoantibodies to ss-DNA were detected in 15.8% of cases. Quantitative evaluation of the serum level of IgG autoantibodies to ds-DNA revealed an increase by 1.6 times in patients with pemphigus as compared to the control group (p<0.05). The data obtained have diagnostic and prognostic value for the clinical course of the disease. In our opinion, the serum level of IgG autoantibodies should be taken into account for choosing optimal treatment strategies.
Keywords: acantholytic pemphigus, autoantibodies, autoimmunity, immunological markers, anti-double stranded DNA antibodies.